Workpackage 3: Risk
In the third work package (WP3) of OBELIX, data obtained in a multidisciplinary setting will be combined in order to evaluate the weight of evidence that endocrine disrupting chemicals which are present in food and to which unborn babies are exposed may have effects on regulation of appetite and energy expenditure with possible consequences for risks of obesity and related disorders later in life. We will evaluate to which extent current levels of EDCs present in food are risk factors for obesity later in life. By comparing cohorts in different European regions, we will evaluate the importance of differences in dietary intake for the observed effects. Different diets may not only yield different levels of food contaminants but may also differ in nutritional and caloric values. These aspects may affect the health outcome data and should be included in the final risk assessment. From epidemiological studies and from animal studies, bench mark doses will be calculated which will allow comparison of the potentially observed effect with well known effects of the endocrine disrupting chemicals on other targets such as reproduction, neurobehaviour and immune changes. Based on the analysis of the mode of action, we will evaluate the extent to which the results can be extrapolated to a broader range of endocrine disruptors. The chemicals that we have selected are tracers for a whole set of endocrine disrupting chemicals and we will evaluate the possibility to extrapolate the results to other chemicals. The current evaluation schemes of endocrine disrupting chemicals have resulted in a priority list of 553 chemicals, which have been evaluated on their ED properties (e.g European Commission, 2000, 2002a&b, 2006). The results of the risk evaluation may help in prioritising endocrine disrupting chemicals for further safety evaluation and safety measures.