Belongs to workpackage health

P4: NIPH


Beneficiary 4. NIPH - Nasjonalt Folkehelseinstitutt (Norwegian Institute of Public Health), Division of Epidemiology, Oslo, Norway

Beneficiary description - The Department of Genes and Environment in the Division of Epidemiology at The Norwegian Institute of Public Health is responsible for conducting large cohort studies based on the general Norwegian population, with the aim of discovering causes of diseases. The department brings together expertise in biostatistics, environmental epidemiology and molecular biology.

Key personnel - Merete Eggesbo MD, PhD, senior researcher, is an epidemiologist with main interests in persistent environmental toxicants and child health. She is the founder and principal investigator of the Norwegian Human Milk Study (HUMIS), which aims at assessing the effect of exposure to persistent environmental toxicants on child health. At NFI, she works closely with The National Institute of Environmental Sciences (NIEHS, North Carolina, US) involving research on the environmental samples in MoBA (Norwegian mother child cohort of 100 000 children). Furthermore, she is responsible for Norway’s contribution to the WHO monitoring program of environmental pollutants in milk. Per Magnus, Md, PhD, is head of Department of Genes and Environment (NIPH), adjunct professor of Community Health at the University of Oslo and the PI of the Norwegian Mother and Child Cohort Study. He has worked in general epidemiology for 20 years and will provide general guidance as well as facilitate the use of data and samples from the MoBa study.
Key role - A cohort of 2000 children in whom growth has been closely monitored will be utilized for this project. Human milk has been sampled from the mothers after birth and a wide range of environmental toxicants have been analyzed in sub-samples of 400 children, including brominated flame retardants, organochlorines and PCBs, as well as dioxins and furans in 60 children (The Norwegian Human Milk Study (HUMIS)). Blood and DNA are available from a sub-set of these children as well. The cohort will be useful for testing associations between environmental toxicants and growth/obesity development during childhood.

Key References
Magnus P, Irgens LM, Haug K, Nystad W, Skjaerven R, Stoltenberg C, Moba study group: Elin Alsaker E, Bakketeig LS, Daltveit AK, Eggesbø M, Eide J, Hareide B, Haugen M, Hovengen R, Lie KK, Lie RT, Meltzer HT, Nilsen R, Nordhagen R, Paltiel L, Reichborn-Kjennerud T, Rønningen KS, Schreuder P, Stensrud N, Sunde A, Tell GS, Vollset SE and Wiik J.2006. Cohort Profile: The Norwegian Mother and Child Cohort Study. Int J Epidemiol 35, 1146-1150
• Ronningen KS, Paltiel L, Meltzer H, Nordhagen R, Lie K K, Hovengen R, haugen M, Nystad W, Magnus P, Hoppin J. The Biobank of the Norwegian Mother and Child cohort study - A resource for the next 100 years. (2006) Eur J Epidemiol. 21, 619-625.
• Rudi K, Zimonja, M, Kvenshagen B, Rugtveit J, Midtvedt T, Eggesbø M. (2007). Alignment-independent comparisons of human GI-tract microbial 3 communities in a multidimensional 16S rRNA gene evolutionary space.. Applied and Environmental Microbiology. 73, 2727-2734.
Eggesbø M. 2003. Is delivery by cesarean section a risk factor for food allergy. J Allergy Clin Immunology. 112 (2) 420-426.

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